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Formulation Studies of InhA inhibitors and Combination therapy to improve efficacy against Mycobacterium tuberculosis
Previously, structure-based drug design was used to develop substituted diphenyl ethers with potency against the Mycobacterium tuberculosis (Mtb) enoyl-ACP reductase (InhA), however, the highly lipophilic centroid compound, SB-PT004, lacked sufficient efficacy in the acute murine Mtb infection model...
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| Publicado no: | Tuberculosis (Edinb) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117134/ https://ncbi.nlm.nih.gov/pubmed/27865404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2016.07.016 |
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