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Formulation Studies of InhA inhibitors and Combination therapy to improve efficacy against Mycobacterium tuberculosis

Previously, structure-based drug design was used to develop substituted diphenyl ethers with potency against the Mycobacterium tuberculosis (Mtb) enoyl-ACP reductase (InhA), however, the highly lipophilic centroid compound, SB-PT004, lacked sufficient efficacy in the acute murine Mtb infection model...

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Podrobná bibliografie
Vydáno v:Tuberculosis (Edinb)
Hlavní autoři: Knudson, Susan E., Cummings, Jason E., Bommineni, Gopal R., Pan, Pan, Tonge, Peter J., Slayden, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117134/
https://ncbi.nlm.nih.gov/pubmed/27865404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2016.07.016
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