Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

[Image: see text] Tuberculosis (TB) remains a leading cause of mortality among infectious diseases worldwide. InhA has been the focus of numerous drug discovery efforts as this is the target of the first line pro-drug isoniazid. However, with resistance to this drug becoming more common, the aim has...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G., Dias, David M. G., Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232676/
https://ncbi.nlm.nih.gov/pubmed/32240584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00007
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