Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

Our findings reported herein provide support for the benefits of including functional group complexity (FGC) within fragments when screening against protein targets such as Mycobacterium tuberculosis InhA. We show that InhA fragment actives with FGC maintained their binding pose during elaboration....

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Publicado en:ChemMedChem
Autores principales: Prati, Federica, Zuccotto, Fabio, Fletcher, Daniel, Convery, Maire A., Fernandez‐Menendez, Raquel, Bates, Robert, Encinas, Lourdes, Zeng, Jingkun, Chung, Chun‐wa, De Dios Anton, Paco, Mendoza‐Losana, Alfonso, Mackenzie, Claire, Green, Simon R., Huggett, Margaret, Barros, David, Wyatt, Paul G., Ray, Peter C.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915743/
https://ncbi.nlm.nih.gov/pubmed/29399991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700774
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