Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

Our findings reported herein provide support for the benefits of including functional group complexity (FGC) within fragments when screening against protein targets such as Mycobacterium tuberculosis InhA. We show that InhA fragment actives with FGC maintained their binding pose during elaboration....

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Bibliografski detalji
Izdano u:ChemMedChem
Glavni autori: Prati, Federica, Zuccotto, Fabio, Fletcher, Daniel, Convery, Maire A., Fernandez‐Menendez, Raquel, Bates, Robert, Encinas, Lourdes, Zeng, Jingkun, Chung, Chun‐wa, De Dios Anton, Paco, Mendoza‐Losana, Alfonso, Mackenzie, Claire, Green, Simon R., Huggett, Margaret, Barros, David, Wyatt, Paul G., Ray, Peter C.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Communications
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915743/
https://ncbi.nlm.nih.gov/pubmed/29399991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700774
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