Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

Our findings reported herein provide support for the benefits of including functional group complexity (FGC) within fragments when screening against protein targets such as Mycobacterium tuberculosis InhA. We show that InhA fragment actives with FGC maintained their binding pose during elaboration....

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:ChemMedChem
Główni autorzy: Prati, Federica, Zuccotto, Fabio, Fletcher, Daniel, Convery, Maire A., Fernandez‐Menendez, Raquel, Bates, Robert, Encinas, Lourdes, Zeng, Jingkun, Chung, Chun‐wa, De Dios Anton, Paco, Mendoza‐Losana, Alfonso, Mackenzie, Claire, Green, Simon R., Huggett, Margaret, Barros, David, Wyatt, Paul G., Ray, Peter C.
Format: Artigo
Język:Inglês
Wydane: John Wiley and Sons Inc. 2018
Hasła przedmiotowe:
Communications
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915743/
https://ncbi.nlm.nih.gov/pubmed/29399991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700774
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