Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Millions of individuals are infected with and die from tuberculosis (TB) each year, and multidrug-resistant (MDR) strains of TB are increasingly prevalent. As such, there is an urgent need to identify novel drugs to treat TB infections. Current frontline therapies include the drug isoniazid, which i...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn M., Sigel, Eric A., Troast, Dawn M., Zhang, Ying, Ferguson, Andrew D., Davies, Gareth, Stead, Eleanor R., Breed, Jason, Madhavapeddi, Prashanti, Read, Jon A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2016
Θέματα:
PNAS Plus
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150407/
https://ncbi.nlm.nih.gov/pubmed/27864515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610978113
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