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Time-dependent diaryl ether inhibitors of InhA: SAR studies of enzyme inhibition, antibacterial activity, and in vivo efficacy

The diaryl ethers are a novel class of antituberculosis drug candidates that inhibit InhA, the enoyl-ACP reductase involved in the fatty acid biosynthesis (FASII) pathway, and have antibacterial activity against both drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. In the pre...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Pan, Pan, Knudson, Susan, Bommineni, Gopal R., Li, Huei-Jiun, Lai, Cheng-Tsung, Liu, Nina, Garcia-Diaz, Miguel, Simmerling, Carlos, Patil, Sachindra S., Slayden, Richard A., Tonge, Peter J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126670/
https://ncbi.nlm.nih.gov/pubmed/24616444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300429
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