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Slow-Onset Inhibition of Mycobacterium tuberculosis InhA: Revealing Molecular Determinants of Residence Time by MD Simulations
An important kinetic parameter for drug efficacy is the residence time of a compound at a drug target, which is related to the dissociation rate constant k(off). For the essential antimycobacterial target InhA, this parameter is most likely governed by the ordering of the flexible substrate binding...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440617/ https://ncbi.nlm.nih.gov/pubmed/25996598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127009 |
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