Rational modulation of the induced-fit conformational change for slow-onset inhibition in M. tuberculosis InhA

Slow-onset enzyme inhibitors are the subject of considerable interest as an approach to increase potency of pharmaceutical compounds by extending the residence time of the inhibitor on the target (the lifetime of the drug-receptor complex). However, rational modulation of residence time presents sig...

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Vydáno v:Biochemistry
Hlavní autoři: Lai, Cheng-Tsung, Lic, Huei-Jiun, Yu, Weixuan, Shah, Sonam, Bommineni, Gopal R., Perrone, Victoria, Garcia-Diaz, Miguel, Tonge, Peter J., Simmerling, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805124/
https://ncbi.nlm.nih.gov/pubmed/26147157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00284
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