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Evaluating the contribution of transition state destabilization to changes in the residence time of triazole-based InhA inhibitors
A critical goal of lead compound selection and optimization is to maximize target engagement whilst minimizing off-target binding. Since target engagement is a function of both the thermodynamics and kinetics of drug-target interactions, it follows that the structures of both the ground states and t...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Am Chem Soc |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357606/ https://ncbi.nlm.nih.gov/pubmed/28151657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11148 |
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