Rational Optimization of Diphenyl Ether Binding Kinetics to the Enoyl-ACP Reductase FabI1 from Burkholderia pseudomallei

There is growing awareness of the link between drug-target residence time and in vivo drug activity, and there are increasing efforts to determine the molecular factors that control the lifetime of a drug-target complex. Rational alterations in drug-target residence time require knowledge of both th...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Neckles, Carla, Eltschkner, Sandra, Cummings, Jason E., Hirschbeck, Maria, Daryaee, Fereidoon, Bommineni, Gopal R., Zhang, Zhuo, Spagnuolo, Lauren, Yu, Weixuan, Davoodi, Shabnam, Slayden, Richard A., Kisker, Caroline, Tonge, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401771/
https://ncbi.nlm.nih.gov/pubmed/28225601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01048
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