Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase

The enoyl-ACP reductase (ENR) catalyzes the last reaction in the elongation cycle of the bacterial type II fatty acid biosynthesis (FAS-II) pathway. While the FabI ENR is a well validated drug target in organisms such as Mycobacterium tuberculosis and Staphylococcus aureus, alternate ENR isoforms ha...

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Pubblicato in:Biochemistry
Autori principali: Neckles, Carla, Pschibul, Annica, Lai, Cheng-Tsung, Hirschbeck, Maria, Kuper, Jochen, Davoodi, Shabnam, Zou, Junjie, Liu, Nina, Pan, Pan, Shah, Sonam, Daryaee, Fereidoon, Bommineni, Gopal R., Lai, Cristina, Simmerling, Carlos, Kisker, Caroline, Tonge, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887296/
https://ncbi.nlm.nih.gov/pubmed/27136302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01301
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