Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase

Drug–target kinetics enable time-dependent changes in target engagement to be quantified as a function of drug concentration. When coupled to drug pharmacokinetics (PK), drug–target kinetics can thus be used to predict in vivo pharmacodynamics (PD). Previously we described a mechanistic PK/PD model...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Daryaee, Fereidoon, Chang, Andrew, Schiebel, Johannes, Lu, Yang, Zhang, Zhuo, Kapilashrami, Kanishk, Walker, Stephen G., Kisker, Caroline, Sotriffer, Christoph A., Fisher, Stewart L., Tonge, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988406/
https://ncbi.nlm.nih.gov/pubmed/27547299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01000h
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