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The Burkholderia pseudomallei Enoyl-Acyl Carrier Protein Reductase FabI1 Is Essential for In Vivo Growth and Is the Target of a Novel Chemotherapeutic with Efficacy

The bacterial fatty acid biosynthesis pathway is a validated target for the development of novel chemotherapeutics. However, since Burkholderia pseudomallei carries genes that encode both FabI and FabV enoyl-acyl carrier protein (ACP) reductase homologues, the enoyl-ACP reductase that is essential f...

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書誌詳細
主要な著者: Cummings, Jason E., Kingry, Luke C., Rholl, Drew A., Schweizer, Herbert P., Tonge, Peter J., Slayden, Richard A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910854/
https://ncbi.nlm.nih.gov/pubmed/24277048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00176-13
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