Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

Thiolactomycin inhibits bacterial cell growth through inhibition of the β-ketoacyl-ACP synthase activity of type II fatty acid synthases. The effect of modifications of the 5-position isoprenoid side chain on both IC(50) and MIC were determined. Synthesis and screening of a structurally diverse set...

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Detalhes bibliográficos
Main Authors: Kim, Pilho, Zhang, Yong-Mei, Shenoy, Gautham, Nguyen, Quynh-Anh, Boshoff, Helena I., Manjunatha, Ujjini H., Goodwin, Michael, Lonsdale, John, Price, Allen C., Miller, Darcie J., Duncan, Ken, White, Stephen W., Rock, Charles O., Barry, Clifton E., Dowd, Cynthia S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462948/
https://ncbi.nlm.nih.gov/pubmed/16392800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050825p
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