Structure-activity relationships of antitubercular nitroimidazoles. I. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles

The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium tuberculosis (Mtb) while 5-nitroimidazoles like metronidazole are active against only anaerobic Mtb. We have synthesized analogs of both 4- and 5-nitroimidazoles and explored their antitubercular activities. The nitro...

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Hlavní autoři: Kim, Pilho, Zhang, Liang, Manjunatha, Ujjini H., Singh, Ramandeep, Patel, Sejal, Jiricek, Jan, Keller, Thomas H., Boshoff, Helena I., Barry, Clifton E., Dowd, Cynthia S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765526/
https://ncbi.nlm.nih.gov/pubmed/19209889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801246z
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