Structure-Activity Relationships of Antitubercular Nitroimidazoles. II. Determinants of aerobic activity and quantitative structure-activity relationships

The (S)-2-nitro-6-substituted 6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines have been extensively explored for their potential use as new antituberculars based on their excellent bactericidal properties on aerobic whole cells of Mycobacterium tuberculosis. An oxygen atom at the 2-position of the imidaz...

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Autori principali: Kim, Pilho, Kang, Sunhee, Boshoff, Helena I., Jiricek, Jan, Collins, Margaret, Singh, Ramandeep, Manjunatha, Ujjini H., Niyomrattanakit, Pornwaratt, Zhang, Liang, Goodwin, Michael, Dick, Thomas, Keller, Thomas H., Dowd, Cynthia S., Barry, Clifton E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765540/
https://ncbi.nlm.nih.gov/pubmed/19209893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801374t
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