PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for their biological function. We found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolit...

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Main Authors: Singh, Ramandeep, Manjunatha, Ujjini, Boshoff, Helena I. M., Ha, Young Hwan, Niyomrattanakit, Pornwaratt, Ledwidge, Richard, Dowd, Cynthia S., Lee, Ill Young, Kim, Pilho, Zhang, Liang, Kang, Sunhee, Keller, Thomas H., Jiricek, Jan, Barry, Clifton E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723733/
https://ncbi.nlm.nih.gov/pubmed/19039139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164571
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