PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for their biological function. We found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Singh, Ramandeep, Manjunatha, Ujjini, Boshoff, Helena I. M., Ha, Young Hwan, Niyomrattanakit, Pornwaratt, Ledwidge, Richard, Dowd, Cynthia S., Lee, Ill Young, Kim, Pilho, Zhang, Liang, Kang, Sunhee, Keller, Thomas H., Jiricek, Jan, Barry, Clifton E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723733/
https://ncbi.nlm.nih.gov/pubmed/19039139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164571
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