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A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism
DNA gyrase is a DNA topoisomerase indispensable for cellular functions in bacteria. We describe a novel, hitherto unknown, mechanism of specific inhibition of Mycobacterium smegmatis and Mycobacterium tuberculosis DNA gyrase by a monoclonal antibody (mAb). Binding of the mAb did not affect either Gy...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1142348/ https://ncbi.nlm.nih.gov/pubmed/15930158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki622 |
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