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Molecular Basis for the Differential Quinolone Susceptibility of Mycobacterial DNA Gyrase
DNA gyrase is a type II topoisomerase that catalyzes the introduction of negative supercoils in the genomes of eubacteria. Fluoroquinolones (FQs), successful as drugs clinically, target the enzyme to trap the gyrase-DNA complex, leading to the accumulation of double-strand breaks in the genome. Myco...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4023751/ https://ncbi.nlm.nih.gov/pubmed/24419347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01958-13 |
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