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Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB
DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials. The majority of mutations conferring resistance to quinolones arise within the quinolone resistance-determining region of GyrA close to the active site (Tyr(122)) where DNA is bound and cleaved. However...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC127264/ https://ncbi.nlm.nih.gov/pubmed/12019094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1805-1815.2002 |
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