Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB
DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials. The majority of mutations conferring resistance to quinolones arise within the quinolone resistance-determining region of GyrA close to the active site (Tyr(122)) where DNA is bound and cleaved. However...
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| Опубликовано в:: | Antimicrob Agents Chemother |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019094/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1805-1815.2002 |
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