Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB

DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials. The majority of mutations conferring resistance to quinolones arise within the quinolone resistance-determining region of GyrA close to the active site (Tyr(122)) where DNA is bound and cleaved. However...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Heddle, Jonathan, Maxwell, Anthony
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019094/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1805-1815.2002
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