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Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB

DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials. The majority of mutations conferring resistance to quinolones arise within the quinolone resistance-determining region of GyrA close to the active site (Tyr(122)) where DNA is bound and cleaved. However...

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Détails bibliographiques
Auteurs principaux: Heddle, Jonathan, Maxwell, Anthony
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC127264/
https://ncbi.nlm.nih.gov/pubmed/12019094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1805-1815.2002
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