Structure-Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824)

The (S)-2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine named PA-824 (1) has demonstrated antitubercular activity in vitro and in animal models and is currently in clinical trials. We synthesized derivatives at three positions of the 4-(trifluoromethoxy)benzylamin...

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Main Authors: Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael, Lakshminarayana, Suresh B., Niyomrattanakit, Pornwaratt, Jiricek, Jan, Ravindran, Sindhu, Dick, Thomas, Keller, Thomas H., Dartois, Veronique, Barry, Clifton E.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158291/
https://ncbi.nlm.nih.gov/pubmed/21755942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1010644
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