Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

[Image: see text] Methionyl-tRNA synthetase (MetRS) has been chemically validated as a drug target in the kinetoplastid parasite Trypanosoma brucei. In the present study, we investigate the validity of this target in the related trypanosomatid Leishmania donovani. Following development of a robust h...

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Foilsithe in:ACS Infect Dis
Main Authors: Torrie, Leah S., Brand, Stephen, Robinson, David A., Ko, Eun Jung, Stojanovski, Laste, Simeons, Frederick R. C., Wyllie, Susan, Thomas, John, Ellis, Lucy, Osuna-Cabello, Maria, Epemolu, Ola, Nühs, Andrea, Riley, Jennifer, MacLean, Lorna, Manthri, Sujatha, Read, Kevin D., Gilbert, Ian H., Fairlamb, Alan H., De Rycker, Manu
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2017
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663395/
https://ncbi.nlm.nih.gov/pubmed/28967262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00047
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