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Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening condition that has become a global issue. Current treatment is limited to two medicines that require prolonged dosing and are associated with multiple side effects, which often lead to treatment di...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Zmuda, Filip, Sastry, Lalitha, Shepherd, Sharon M., Jones, Deuan, Scott, Alison, Craggs, Peter D., Cortes, Alvaro, Gray, David W., Torrie, Leah S., De Rycker, Manu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709497/
https://ncbi.nlm.nih.gov/pubmed/31307977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00309-19
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