Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

[Image: see text] Methionyl-tRNA synthetase (MetRS) is a chemically validated drug target in kinetoplastid parasites Trypanosoma brucei and Leishmania donovani. To date, all kinetoplastid MetRS inhibitors described bind in a similar way to an expanded methionine pocket and an adjacent, auxiliary poc...

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Publicado en:ACS Infect Dis
Autores principales: Torrie, Leah S., Robinson, David A., Thomas, Michael G., Hobrath, Judith V., Shepherd, Sharon M., Post, John M., Ko, Eun-Jung, Ferreira, Rafael Alves, Mackenzie, Claire J., Wrobel, Karolina, Edwards, Darren P., Gilbert, Ian H., Gray, David W., Fairlamb, Alan H., De Rycker, Manu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294809/
https://ncbi.nlm.nih.gov/pubmed/32275825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00453
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