Probing the Role of HDACs and Mechanisms of Chromatin-Mediated Neuroplasticity

Por Haggarty, Stephen J., Tsai, Li-Huei
Publicado em 2011

Translation: Screening for Novel Therapeutics Using Disease-Relevant Cell Types Derived from Human Stem Cell Models

Por Haggarty, Stephen J., Perlis, Roy H.
Publicado em 2013

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

Por Silva, M. Catarina, Haggarty, Stephen J.
Publicado no Int J Mol Sci (2020)

Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future

Por Alural, Begum, Genc, Sermin, Haggarty, Stephen J.
Publicado no Prog Neuropsychopharmacol Biol Psychiatry (2016)

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch

Por Ricq, Emily L., Hooker, Jacob M., Haggarty, Stephen J.
Publicado no J Biol Chem (2016)

Toward Development of Epigenetic Drugs for CNS Disorders: Modulating Neuroplasticity via H3K4 Methylation

Por Ricq, Emily L., Hooker, Jacob M., Haggarty, Stephen J.
Publicado no Psychiatry Clin Neurosci (2016)

SpectralNET – an application for spectral graph analysis and visualization

Por Forman, Joshua J, Clemons, Paul A, Schreiber, Stuart L, Haggarty, Stephen J
Publicado em 2005

Epigenetic Mechanisms in Mood Disorders: Targeting Neuroplasticity

Por Fass, Daniel M., Schroeder, Frederick A., Perlis, Roy H., Haggarty, Stephen J.
Publicado em 2013

Advancing Drug Discovery for Neuropsychiatric Disorders Using Patient-Specific Stem Cell Models

Por Haggarty, Stephen J., Silva, M. Catarina, Cross, Alan, Brandon, Nicholas J., Perlis, Roy H.
Publicado no Mol Cell Neurosci (2016)

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Por Haggarty, Stephen J., Koeller, Kathryn M., Wong, Jason C., Grozinger, Christina M., Schreiber, Stuart L.
Publicado em 2003

Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening

Por Cheng, Chialin, Fass, Daniel M., Folz-Donahue, Kat, MacDonald, Marcy E., Haggarty, Stephen J.
Publicado no Curr Protoc Hum Genet (2017)

Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells

Por Iaconelli, Jonathan, Lalonde, Jasmin, Watmuff, Bradley, Liu, Bangyan, Mazitschek, Ralph, Haggarty, Stephen J., Karmacharya, Rakesh
Publicado no ACS Chem Biol (2017)

Chemical Genetics Identifies Small-Molecule Modulators of Neuritogenesis Involving Neuregulin-1/ErbB4 Signaling

Por Kuai, Letian, Wang, Xiang, Madison, Jon M., Schreiber, Stuart L., Scolnick, Edward M., Haggarty, Stephen J.
Publicado em 2010

Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration

Por Samara, Chrysanthi, Rohde, Christopher B., Gilleland, Cody L., Norton, Stephanie, Haggarty, Stephen J., Yanik, Mehmet Fatih
Publicado em 2010

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Por Moreno-Yruela, Carlos, Fass, Daniel M., Cheng, Chialin, Herz, Joachim, Olsen, Christian A., Haggarty, Stephen J.
Publicado no ACS Chem Neurosci (2019)

A High-Throughput Screen for Wnt/β-catenin Signaling Pathway Modulators in Human iPSC-derived Neural Progenitors

Por Zhao, Wen-Ning, Cheng, Chialin, Theriault, Kraig M., Sheridan, Steven D., Tsai, Li-Huei, Haggarty, Stephen J.
Publicado em 2012

Chemical Phylogenetics of Histone Deacetylases

Por Bradner, James E., West, Nathan, Grachan, Melissa L., Greenberg, Edward F., Haggarty, Stephen J., Warnow, Tandy, Mazitschek, Ralph
Publicado em 2010

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

Por Huang, Jing, Zhu, Heng, Haggarty, Stephen J., Spring, David R., Hwang, Heejun, Jin, Fulai, Snyder, Michael, Schreiber, Stuart L.
Publicado em 2004

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

Por Kilgore, Mark, Miller, Courtney A, Fass, Daniel M, Hennig, Krista M, Haggarty, Stephen J, Sweatt, J David, Rumbaugh, Gavin
Publicado em 2010

β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome

Por Mellios, Nikolaos, Woodson, Jonathan, Garcia, Rodrigo I., Crawford, Benjamin, Sharma, Jitendra, Sheridan, Steven D., Haggarty, Stephen J., Sur, Mriganka
Publicado em 2014