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Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by cognitive impairments that progress to dementia and death. The earliest symptoms of AD present as a relatively pure deficit in memory retrieval. Therefore, drug treatments that intervene in the early stages of...

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Detalhes bibliográficos
Main Authors: Kilgore, Mark, Miller, Courtney A, Fass, Daniel M, Hennig, Krista M, Haggarty, Stephen J, Sweatt, J David, Rumbaugh, Gavin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055373/
https://ncbi.nlm.nih.gov/pubmed/20010553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.197
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