Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor

Friedreich ataxia, the most prevalent inherited ataxia, is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene. Repressive chromatin spreads from the expanded GAA triplet-repeat sequence to cause epigenetic silencing of the FXN promoter via altered nucleosomal positioning a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Chutake, Yogesh K., Lam, Christina C., Costello, Whitney N., Anderson, Michael P., Bidichandani, Sanjay I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914082/
https://ncbi.nlm.nih.gov/pubmed/26896803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw107
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi