Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor

Friedreich ataxia, the most prevalent inherited ataxia, is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene. Repressive chromatin spreads from the expanded GAA triplet-repeat sequence to cause epigenetic silencing of the FXN promoter via altered nucleosomal positioning a...

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Publicat a:Nucleic Acids Res
Autors principals: Chutake, Yogesh K., Lam, Christina C., Costello, Whitney N., Anderson, Michael P., Bidichandani, Sanjay I.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914082/
https://ncbi.nlm.nih.gov/pubmed/26896803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw107
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