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Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor
Friedreich ataxia, the most prevalent inherited ataxia, is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene. Repressive chromatin spreads from the expanded GAA triplet-repeat sequence to cause epigenetic silencing of the FXN promoter via altered nucleosomal positioning a...
Tallennettuna:
| Julkaisussa: | Nucleic Acids Res |
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| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914082/ https://ncbi.nlm.nih.gov/pubmed/26896803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw107 |
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