Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia

Most individuals with Friedreich ataxia (FRDA) are homozygous for an expanded GAA triplet repeat (GAA-TR) mutation in intron 1 of the FXN gene, which results in deficiency of FXN transcript. Consistent with the expanded GAA-TR sequence as a cause of variegated gene silencing, evidence for heterochro...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chutake, Yogesh K., Costello, Whitney N., Lam, Christina, Bidichandani, Sanjay I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140879/
https://ncbi.nlm.nih.gov/pubmed/24737321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566414
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