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FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia
BACKGROUND: Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter. This silencing mechanism is seen in patient-derived lymphoblastoid cells but it remains unknown if it is a widespread phenomenon af...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4579136/ https://ncbi.nlm.nih.gov/pubmed/26393353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138437 |
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