A High-Throughput Screen for Wnt/β-catenin Signaling Pathway Modulators in Human iPSC-derived Neural Progenitors

Por Zhao, Wen-Ning, Cheng, Chialin, Theriault, Kraig M., Sheridan, Steven D., Tsai, Li-Huei, Haggarty, Stephen J.
Publicado em 2012

Dissecting Structure-Activity-Relationships of Crebinostat: Brain Penetrant HDAC Inhibitors for Neuroepigenetic Regulation

Por Ghosh, Balaram, Zhao, Wen-Ning, Reis, Surya A., Patnaik, Debasis, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.
Publicado no Bioorg Med Chem Lett (2016)

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

Por Lalonde, Jasmin, Reis, Surya A., Sivakumaran, Sudhir, Holland, Carl S., Wesseling, Hendrik, Sauld, John F., Alural, Begum, Zhao, Wen-Ning, Steen, Judith A., Haggarty, Stephen J.
Publicado no Nat Commun (2017)

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Por She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.
Publicado no Cell Chem Biol (2017)

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

Por Fass, Daniel M., Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A., Klein, Peter S., Mazitschek, Ralph, Maglathlin, Rebecca L., Lewis, Timothy A., Haggarty, Stephen J.
Publicado em 2010

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

Por Beauchamp, Roberta L., James, Marianne F., DeSouza, Patrick A., Wagh, Vilas, Zhao, Wen-Ning, Jordan, Justin T., Stemmer-Rachamimov, Anat, Plotkin, Scott R., Gusella, James F., Haggarty, Stephen J., Ramesh, Vijaya
Publicado no Oncotarget (2015)

HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination

Por Strebl, Martin G., Campbell, Arthur J., Zhao, Wen-Ning, Schroeder, Frederick A., Riley, Misha M., Chindavong, Peter S., Morin, Thomas M., Haggarty, Stephen J., Wagner, Florence F., Ritter, Tobias, Hooker, Jacob M.
Publicado no ACS Cent Sci (2017)

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca(2+) Homeostasis, Autophagy, and CLN3 Protein Function

Por Chandrachud, Uma, Walker, Mathew W., Simas, Alexandra M., Heetveld, Sasja, Petcherski, Anton, Klein, Madeleine, Oh, Hyejin, Wolf, Pavlina, Zhao, Wen-Ning, Norton, Stephanie, Haggarty, Stephen J., Lloyd-Evans, Emyr, Cotman, Susan L.
Publicado no J Biol Chem (2015)

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4

Por Hennig, Krista M., Fass, Daniel M., Zhao, Wen-Ning, Sheridan, Steven D., Fu, Ting, Erdin, Serkan, Stortchevoi, Alexei, Lucente, Diane, Cody, Jannine D., Sweetser, David, Gusella, James F., Talkowski, Michael E., Haggarty, Stephen J.
Publicado no Mol Neuropsychiatry (2017)

A Screen for Regulators of Survival of Motor Neuron Protein Levels

Por Makhortova, Nina R., Hayhurst, Monica, Cerqueira, Antonio, Sinor-Anderson, Amy D., Zhao, Wen-Ning, Heiser, Patrick W., Arvanites, Anthony C., Davidow, Lance S., Waldon, Zachary O., Steen, Judith A., Lam, Kelvin, Ngo, Hien D., Rubin, Lee L.
Publicado em 2011

Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation

Por Zhou, Zhaolan, Hong, Elizabeth J., Cohen, Sonia, Zhao, Wen-ning, Ho, Hsin-yi Henry, Schmidt, Lauren, Chen, Wen G., Lin, Yingxi, Savner, Erin, Griffith, Eric C., Hu, Linda, Steen, Judith A.J., Weitz, Charles J., Greenberg, Michael E.
Publicado em 2006

Crebinostat: A Novel Cognitive Enhancer that Inhibits Histone Deacetylase Activity and Modulates Chromatin-Mediated Neuroplasticity

Por Fass, Daniel M., Reis, Surya A., Ghosh, Balaram, Hennig, Krista M., Joseph, Nadine F., Zhao, Wen-Ning, Nieland, Thomas J.F., Guan, Ji-Song, Kuhnle, Chelsea E. Groves, Tang, Weiping, Barker, Douglas D., Mazitschek, Ralph, Schreiber, Stuart L., Tsai, Li-Huei, Haggarty, Stephen J.
Publicado em 2012

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

Por Schroeder, Frederick A., Lewis, Michael C., Fass, Daniel M., Wagner, Florence F., Zhang, Yan-Ling, Hennig, Krista M., Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D., Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L., Hooker, Jacob M., Holson, Edward B., Haggarty, Stephen J., Petryshen, Tracey L.
Publicado em 2013

An Aldol-based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Por Marcaurelle, Lisa A., Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R., Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D., Liu, Haibo, Lowe, Jason T., Marie, Jean-Charles, Mulrooney, Carol A., Pandya, Bhaumik A., Rowley, Ann, Ryba, Troy D., Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W., Akella, Lakshmi B., Ross, Nathan T., Zhang, Yan-Ling, Fass, Daniel M., Reis, Surya A., Zhao, Wen-Ning, Haggarty, Stephen J., Palmer, Michelle, Foley, Michael A.
Publicado em 2010

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis

Por Tobe, Brian T. D., Crain, Andrew M., Winquist, Alicia M., Calabrese, Barbara, Makihara, Hiroko, Zhao, Wen-ning, Lalonde, Jasmin, Nakamura, Haruko, Konopaske, Glenn, Sidor, Michelle, Pernia, Cameron D., Yamashita, Naoya, Wada, Moyuka, Inoue, Yuuka, Nakamura, Fumio, Sheridan, Steven D., Logan, Ryan W., Brandel, Michael, Wu, Dongmei, Hunsberger, Joshua, Dorsett, Laurel, Duerr, Cordulla, Basa, Ranor C. B., McCarthy, Michael J., Udeshi, Namrata D., Mertins, Philipp, Carr, Steven A., Rouleau, Guy A., Mastrangelo, Lina, Li, Jianxue, Gutierrez, Gustavo J., Brill, Laurence M., Venizelos, Nikolaos, Chen, Guang, Nye, Jeffrey S., Manji, Husseini, Price, Jeffrey H., McClung, Colleen A., Akiskal, Hagop S., Alda, Martin, Chuang, De-Maw M., Coyle, Joseph T., Liu, Yang, Teng, Yang D., Ohshima, Toshio, Mikoshiba, Katsuhiko, Sidman, Richard L., Halpain, Shelley, Haggarty, Stephen J., Goshima, Yoshio, Snyder, Evan Y.
Publicado no Proc Natl Acad Sci U S A (2017)