Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis

The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern li...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Proc Natl Acad Sci U S A
المؤلفون الرئيسيون: Tobe, Brian T. D., Crain, Andrew M., Winquist, Alicia M., Calabrese, Barbara, Makihara, Hiroko, Zhao, Wen-ning, Lalonde, Jasmin, Nakamura, Haruko, Konopaske, Glenn, Sidor, Michelle, Pernia, Cameron D., Yamashita, Naoya, Wada, Moyuka, Inoue, Yuuka, Nakamura, Fumio, Sheridan, Steven D., Logan, Ryan W., Brandel, Michael, Wu, Dongmei, Hunsberger, Joshua, Dorsett, Laurel, Duerr, Cordulla, Basa, Ranor C. B., McCarthy, Michael J., Udeshi, Namrata D., Mertins, Philipp, Carr, Steven A., Rouleau, Guy A., Mastrangelo, Lina, Li, Jianxue, Gutierrez, Gustavo J., Brill, Laurence M., Venizelos, Nikolaos, Chen, Guang, Nye, Jeffrey S., Manji, Husseini, Price, Jeffrey H., McClung, Colleen A., Akiskal, Hagop S., Alda, Martin, Chuang, De-Maw M., Coyle, Joseph T., Liu, Yang, Teng, Yang D., Ohshima, Toshio, Mikoshiba, Katsuhiko, Sidman, Richard L., Halpain, Shelley, Haggarty, Stephen J., Goshima, Yoshio, Snyder, Evan Y.
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2017
الموضوعات:
PNAS Plus
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465887/
https://ncbi.nlm.nih.gov/pubmed/28500272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700111114
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة