Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation

Mutations or duplications in MECP2 cause Rett and Rett-like syndromes, neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and autistic behaviors. MeCP2 is expressed in many mammalian tissues and functions as a global repressor of transcription; however, the molecula...

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Hlavní autoři: Zhou, Zhaolan, Hong, Elizabeth J., Cohen, Sonia, Zhao, Wen-ning, Ho, Hsin-yi Henry, Schmidt, Lauren, Chen, Wen G., Lin, Yingxi, Savner, Erin, Griffith, Eric C., Hu, Linda, Steen, Judith A.J., Weitz, Charles J., Greenberg, Michael E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962021/
https://ncbi.nlm.nih.gov/pubmed/17046689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2006.09.037
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