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SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300...

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Main Authors: Zocchi, Loredana, Sassone-Corsi, Paolo
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414390/
https://ncbi.nlm.nih.gov/pubmed/22677942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.20733
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