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SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3414390/ https://ncbi.nlm.nih.gov/pubmed/22677942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.20733 |
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