A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

Meningiomas are the most common primary intracranial adult tumor. All Neurofibromatosis 2 (NF2)-associated meningiomas and ~60% of sporadic meningiomas show loss of NF2 tumor suppressor protein. There are no effective medical therapies for progressive and recurrent meningiomas. Our previous work dem...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Beauchamp, Roberta L., James, Marianne F., DeSouza, Patrick A., Wagh, Vilas, Zhao, Wen-Ning, Jordan, Justin T., Stemmer-Rachamimov, Anat, Plotkin, Scott R., Gusella, James F., Haggarty, Stephen J., Ramesh, Vijaya
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627286/
https://ncbi.nlm.nih.gov/pubmed/26219339
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