Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include heterozygous mutations in the GRN gene causing haploinsufficiency of progranulin (PGRN) protein. Recently, histone deacetylase (HDAC) inhibitors...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Chem Biol
Auteurs principaux: She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695697/
https://ncbi.nlm.nih.gov/pubmed/28712747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.06.010
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires