Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include heterozygous mutations in the GRN gene causing haploinsufficiency of progranulin (PGRN) protein. Recently, histone deacetylase (HDAC) inhibitors...

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Bibliografske podrobnosti
izdano v:Cell Chem Biol
Main Authors: She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695697/
https://ncbi.nlm.nih.gov/pubmed/28712747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.06.010
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