Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include heterozygous mutations in the GRN gene causing haploinsufficiency of progranulin (PGRN) protein. Recently, histone deacetylase (HDAC) inhibitors...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Chem Biol
Autori principali: She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695697/
https://ncbi.nlm.nih.gov/pubmed/28712747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.06.010
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi