Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include heterozygous mutations in the GRN gene causing haploinsufficiency of progranulin (PGRN) protein. Recently, histone deacetylase (HDAC) inhibitors...

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Publicado no:Cell Chem Biol
Main Authors: She, Angela, Kurtser, Iren, Reis, Surya A., Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C., Herz, Joachim, Haggarty, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695697/
https://ncbi.nlm.nih.gov/pubmed/28712747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.06.010
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