Young systemic factors as a medicine for age-related neurodegenerative diseases

Por Katsimpardi, Lida, Rubin, Lee L
Publicado no Neurogenesis (Austin) (2015)

Stem cell biology and drug discovery

Por Haston Kelly M, Rubin Lee L
Publicado em 2011-06-01

Stem cell biology and drug discovery

Por Rubin, Lee L, Haston, Kelly M
Publicado em 2011

Drug discovery using neurons derived from patients: Studying Human Disease Using Human Neurons

Por Ahfeldt, Tim, Litterman, Nadia K., Rubin, Lee L.
Publicado no Brain Res (2016)

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

Por Bazenet, Chantal E., Mota, Mónica A., Rubin, Lee L.
Publicado em 1998

Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis

Por Neame, Stephen J., Rubin, Lee L., Philpott, Karen L.
Publicado em 1998

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

Por Philpott, Karen L., McCarthy, Mary Jane, Klippel, Anke, Rubin, Lee L.
Publicado em 1997

A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein

Por Hayhurst, Monica, Wagner, Amanda K., Cerletti, Massimiliano, Wagers, Amy J., Rubin, Lee L.
Publicado em 2012

Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons

Por Kanamoto, Takashi, Mota, Monica, Takeda, Kohsuke, Rubin, Lee L., Miyazono, Kohei, Ichijo, Hidenori, Bazenet, Chantal E.
Publicado em 2000

Genome-Wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

Por Ng, Shi-Yan, Soh, Boon Seng, Rodriguez-Muela, Natalia, Hendrickson, David G., Price, Feodor, Rinn, John L., Rubin, Lee L.
Publicado no Cell Stem Cell (2015)

Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, That Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atroph...

Por Chen, Po C., Gaisina, Irina N., El-Khodor, Bassem F., Ramboz, Sylvie, Makhortova, Nina R., Rubin, Lee L., Kozikowski, Alan P.
Publicado em 2011

Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy

Por Cherry, Jonathan J., Kobayashi, Dione T., Lynes, Maureen M., Naryshkin, Nikolai N., Tiziano, Francesco Danilo, Zaworski, Phillip G., Rubin, Lee L., Jarecki, Jill
Publicado em 2014

Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation

Por Wang, Yu, Arvanites, Anthony C., Davidow, Lance, Blanchard, Joel, Lam, Kelvin, Yoo, Jin Woo, Coy, Shannon, Rubin, Lee L., McMahon, Andrew P.
Publicado em 2012

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Por Rihel, Jason, Prober, David A., Arvanites, Anthony, Lam, Kelvin, Zimmerman, Steven, Jang, Sumin, Haggarty, Stephen J., Kokel, David, Rubin, Lee L., Peterson, Randall T., Schier, Alexander F.
Publicado em 2010

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

Por Blum, Barak, Roose, Adam N, Barrandon, Ornella, Maehr, René, Arvanites, Anthony C, Davidow, Lance S, Davis, Jeffrey C, Peterson, Quinn P, Rubin, Lee L, Melton, Douglas A
Publicado em 2014

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

Por Annes, Justin P., Ryu, Jennifer Hyoje, Lam, Kelvin, Carolan, Peter J., Utz, Katrina, Hollister-Lock, Jennifer, Arvanites, Anthony C., Rubin, Lee L., Weir, Gordon, Melton, Douglas A.
Publicado em 2012

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors

Por Katsimpardi, Lida, Litterman, Nadia K., Schein, Pamela A., Miller, Christine M., Loffredo, Francesco S., Wojtkiewicz, Gregory R., Chen, John W., Lee, Richard T., Wagers, Amy J., Rubin, Lee L.
Publicado em 2014

Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

Por Williams, Juliet A., Guicherit, Oivin M., Zaharian, Beatrice I., Xu, Yin, Chai, Ling, Wichterle, Hynek, Kon, Charlene, Gatchalian, Christine, Porter, Jeffery A., Rubin, Lee L., Wang, Frank Y.
Publicado em 2003

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Por Frank-Kamenetsky, Maria, Zhang, Xiaoyan M, Bottega, Steve, Guicherit, Oivin, Wichterle, Hynek, Dudek, Henryk, Bumcrot, David, Wang, Frank Y, Jones, Simon, Shulok, Janine, Rubin, Lee L, Porter, Jeffery A
Publicado em 2002

Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System

Por Rigamonti, Alessandra, Repetti, Giuliana G., Sun, Chicheng, Price, Feodor D., Reny, Danielle C., Rapino, Francesca, Weisinger, Karen, Benkler, Chen, Peterson, Quinn P., Davidow, Lance S., Hansson, Emil M., Rubin, Lee L.
Publicado no Stem Cell Reports (2016)