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Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
Hedgehog (Hh) signaling promotes tumorigenesis. The accumulation of a membrane protein Smoothened (Smo) within the primary cilium (PC) is a key event in Hh signal transduction and many pharmacological inhibitors identified to date target Smo’s actions. Smo ciliary translocation is inhibited by some...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905677/ https://ncbi.nlm.nih.gov/pubmed/22554036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300028a |
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