Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation

Hedgehog (Hh) signaling promotes tumorigenesis. The accumulation of a membrane protein Smoothened (Smo) within the primary cilium (PC) is a key event in Hh signal transduction and many pharmacological inhibitors identified to date target Smo’s actions. Smo ciliary translocation is inhibited by some...

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Main Authors: Wang, Yu, Arvanites, Anthony C., Davidow, Lance, Blanchard, Joel, Lam, Kelvin, Yoo, Jin Woo, Coy, Shannon, Rubin, Lee L., McMahon, Andrew P.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905677/
https://ncbi.nlm.nih.gov/pubmed/22554036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300028a
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