Identification of a potent antagonist of smoothened in hedgehog signaling

BACKGROUND: Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics. Given the close link between aberrant Hedgehog signaling and cancers, many small molecular compounds ha...

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Bibliographic Details
Published in:Cell Biosci
Main Authors: Fan, Junwan, Li, Haowen, Kuang, Lun, Zhao, Zichen, He, Wenyan, Liu, Chen, Wang, Yongjun, Cheng, Steven Y., Chen, Wei
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923671/
https://ncbi.nlm.nih.gov/pubmed/33653381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00558-9
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