CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists

The aberrant hedgehog (Hh) pathway plays important roles in multiple cancer types, therefore serving as a promising drug target. Current clinically available hedgehog-targeted drugs act mostly by antagonizing the upstream component smoothened; however, both primary and acquired resistance to FDA-app...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Fang, Jiang, Wenyan, Sui, Yi, Meng, Wei, Hou, Linjun, Li, Tiantian, Li, Meng, Zhang, Lei, Mo, Jialin, Wang, Jiajia, Zhao, Yang, Zhang, Liye, Ma, Jie, Tang, Yujie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600918/
https://ncbi.nlm.nih.gov/pubmed/31182587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815780116
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