CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists

The aberrant hedgehog (Hh) pathway plays important roles in multiple cancer types, therefore serving as a promising drug target. Current clinically available hedgehog-targeted drugs act mostly by antagonizing the upstream component smoothened; however, both primary and acquired resistance to FDA-app...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Liu, Fang, Jiang, Wenyan, Sui, Yi, Meng, Wei, Hou, Linjun, Li, Tiantian, Li, Meng, Zhang, Lei, Mo, Jialin, Wang, Jiajia, Zhao, Yang, Zhang, Liye, Ma, Jie, Tang, Yujie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600918/
https://ncbi.nlm.nih.gov/pubmed/31182587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815780116
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia