MEDU-06. TARGETING MYC AND OTX2-DRIVEN TRANSCRIPTIONAL DEPENDENCIES OF GROUP 3 MEDULLOBLASTOMA THROUGH CDK7 INHIBITION

Medulloblastoma (MB) is the most frequent malignant childhood brain cancer and Group 3 MB (G3-MB) has the worst prognosis among the four consensus molecular subtypes. In G3-MB, MYC and OTX2 have been shown to be the oncogenic drivers and master transcriptional factors that tumor cells are highly add...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Zhang, Lei, Li, Meng, Hou, Linjun, Zhang, Liye, Tang, Yujie
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Medulloblastoma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477377/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.166
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