MEDU-04. AN OTX2-PAX GENE NETWORK REGULATES GROUP 3 MEDULLOBLASTOMA DIFFERENTIATION AND TUMOR GROWTH

Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Group 3 has the worst prognosis of the MB subgroups and the pathways driving Group 3 pathogenesis are poorly defined. OTX2 is overexpressed/amplified in 80% of Group 3 tumors and maintains the balance between self-renew...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Zagozewski, Jamie, Morrison, Ludivine, Shahriary, Ghazaleh, Stromecki, Margaret, Fresnoza, Agnes, Palidwor, Gareth, Porter, Christopher, Hawkins, Cynthia, Chan, Jennifer, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Medulloblastoma
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477278/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.164
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